Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
‘The Americans’ Set in the Reagan era, this FX series is nearly as deceptive as KGB agents posing as suburban American couple: In its second season, “The Americans” proved to be a drama about love, family, friendship and mistrust disguised as a Cold War thriller.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
15. 《旅行终点》(The End of the Tour) ，导演：詹姆斯·庞索特(James Ponsoldt)。
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Unlike many young girls who are starstruck by celebrities, Maddie claims that she keeps a cool head at events like the Grammys because she sees herself as a star, so needs to act accordingly.
“We will see a lot of headlines about [emerging market export growth] picking up in the first half of 2017,” says Bhanu Baweja, head of EM cross asset strategy at UBS, who believes EM exports will show year-on-year growth of between 8 and 13 per cent in dollar terms in the first quarter of this year, “a complete postcode away” from the negative numbers currently being reported.
Trends and targets in antiviral phototherapy
In the first 10 months of the year, Chinese exports to the US were up 5.2 per cent from the same period in 2014, while exports to countries in Asean were up 3.7 per cent, according to Chinese customs figures.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Coordinated reform of medical services, medical insurance, and the medicine industry
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
May the joy and happiness around you today and always.
The third gunman, Amedy Coulibaly, who stormed a kosher supermarket on Friday,never left for such training, said Valls.
In comparison, second-tier cities reported worsening congestion, an increase of 3.7% on average, with Chongqing, Changchun, Jiaxing and Shenyang leading the rate of growth at over 7%.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Mr Trump is almost a textbook demagogue.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
1. Jennifer Lawrence
Citing recent figures from the CPB Netherlands Bureau for Policy Analysis, that show global trade in seasonally-adjusted volume terms fell 1.1 per cent between September and October, Mr Leering suggests last year will prove to be the worst year for world trade since 2009.
Influenza neuraminidase: A druggable target for natural products
Import growth lifted year-on-year to a pace of 17.7 per cent for the period, up from 17.2 per cent a month earlier and beating an expected rate of 11.3 per cent.
2006年，哈茨与现任丈夫凯文共同创办了在线票务平台Eventbrite。自成立以来，这家公司先后从红杉资本（Sequoia Capital）和老虎全球基金（Tiger Global Management）等公司获得了总计1.4亿美元的投资。今年9月，它的票务销售总额达到了20亿美元。创业让哈茨不得不在与人沟通时运用坦率、且具有合作性的对话方式。她说：“我必须学会如何寻求帮助。所有人都认为创业是勇敢的举动，但我认为，更需要勇气的事情是，把自己摆到众人面前，同时努力达成协作。”
Treating Birth Defects Before a Baby Is Born
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
As the fashion world mourns Lagerfeld, his beloved cat Choupette is one of a number who could be set to inherit his ￡150million fortune.
The role of biosensors in the detection of emerging infectious diseases
Though many people associate Porsche with pure performance cars, in recent years the brand has expanded their lineup to include the Panamera, a luxury large car shown here, as well as the Cayenne and Macan SUVs. According to most reviewers, the Panamera not only lives up to the performance heritage of the Porsche’s brand, but also coddles occupants with an opulent interior and the connectivity features today’s luxury buyer demands.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Politics also color perceptions of the weather, the survey found. More than three-quarters of Democrats and six in 10 independents believe that the weather has become more extreme over the last few years, while less than half of Republicans say they have perceived such a shift.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
这款智能产品的使用可以追溯到1800年，但在2016年它才变得“智能”。 Meet Peggy，这种洗衣挂钩能够“帮助你减轻负担”，它会在洗衣机洗好衣服的时候提醒你，并告诉你天气是否适宜晾晒衣服。该装置连接到您的手机，它会在天气变化或是需要转移晾衣服的地方时发消息提醒你。
After her legal travails , anything Kesha released would have a veneer of triumph. But this comeback set was an artistic warrior cry more potent than any might've expected.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
"Wholesale food prices suggest that pork, vegetable and fruit price inflation all eased last month," said Capital Economics before the figures came out. "
Inhibition of SARS coronavirus helicase by bismuth complexes
I'm amazed that Durant didn't get broken in half back in high school, weighing in at 6'9'', 185 lbs. Lucky for Durant, he doesn't make his money banging against big forwards. He relies on his nasty quick-shot jumper.
9) I would rather keep people at a distance 0 1 2 3 4
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Finding the skill sets and attitudes that support the culture of the brand you want to promote will foster innovation and enhance your reputation. Include folks from outside the company for the people you rely on. That will start a free marketing chain reaction that can build confidence and revenue.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Oh Carmelo, I wish you still had your high school mini-fro. It was absolutely epic.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
His first coding effort resulted in an app that played audio snippets from speeches by his idol, Steve Jobs, whose unauthorized biography he'd recently devoured. 'It was rejected by Apple for every reason,' D'Aloisio says now, laughing. 'Copyrighted audio, poor functionality, too simple.' Another early design allowed users to touch a picture of wood, producing a knocking sound. A third transformed a smartphone screen into a treadmill for your fingers. That one earned about $120 in sales on its first day.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
The magazine also notes that he gave $66 million to his presidential campaign and paid $25 million to settle a lawsuit related to Trump University.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
I’m not saying you should blindly accept everything that’s offered to you, it’s okay to take time when considering the pros and cons of an opportunity. But, when you find yourself leaning toward “No,” you owe it to yourself to be sure that you’re turning down the opportunity for a valid reason, not just out of fear.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
I mean, is it worth to be a No. 8 seed with Serge Ibaka and Jeff Green leading the way? Maybe it is. This all just seems awfully backwards.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Nicole Kidman had daughter Sunday Rose at age 40, with her husband, the country singer Keith Urban. 妮可·基德曼40岁时和其丈夫，乡村歌手凯斯·厄本生下女儿桑迪·
2.SpaceX demonstrates a big step towards fully reusable space craft
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Work that requires German language skills also grew significantly during the third quarter of 2016. Those who wish to work as German translators might be in luck these days.
“温总理的讲话重点提到了经济和社会发展。中国政府为实现建设繁荣社会这一目标付出了巨大的努力。”Irene Giner-Reichl, Austrian ambassador
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
5. The causes of hair loss and greying are linked, and for the first time, scientists have identified the cells responsible.
Frustrated, he invented something that would allow him take a picture of himself: He called it the "extender stick." Since the iPhone really hadn't been invented yet, a small camera was to be attached to one end of the stick. It also had a small mirror in its front so that users could see how they would look in the photograph. He patented the "extender stick" in 1983. The product was mass produced for sale but it was a commercial failure. The quality of the pictures was low. Besides, previous research showed that the women back then were embarrassed by the idea of taking pictures of themselves. The selfie stick was then reinvented by Wayne Fromm in the year 2000, three years before Hiroshi's patent expired. Fromm called his the "quik pod." He believes he is the inventor of today's selfie sticks and has even sued several other selfie stick producers. When asked about Hiroshi's selfie sticks, he said they were "prior art."
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
However, strong progress across the main rankings does not automatically translate into European success. Sa Business School at the University of Oxford, for example, rose one place in the MBA ranking, five places in the ranking of open executive programmes and broke into the top 10 of the Executive MBA ranking for the first time by moving up 12 places, but its European ranking remains unchanged, at 10th.
A modular microarray imaging system for highly specific COVID-19 antibody testing
No. Having ended Robert Mugabe’s 37-year rule — with a little help from the army — Emmerson Mnangagwa has promised free elections in 2018. That raises one problem: he could lose. He must at least pretend elections are fair because he needs donor money to help turn the economy around. That would mean electoral reforms, which risk a loss for his unpopular Zanu-PF. Even if Mr Mnangagwa were prepared to roll the electoral dice, it is not clear the army is. Having got their man in, Zimbabwe’s generals are unlikely to allow the public to kick him out.
其他列入前十的热门搜索项中除了一个以外，都反映了公众对名人的痴迷。青少年热捧的流行小天后麦莉 赛勒斯在热门搜索项中排行第三，紧跟其后排在第四位的是电视明星金 卡戴珊。嘎嘎小姐排在第五位，女演员梅根 福克斯排在第七，前十名的其他几位分别是贾斯汀 比伯、美国偶像和小甜甜布兰妮。排在第六位的iPhone是个例外。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Here are the 10 winners of the 2012 Ig Nobel Prizes given to scientists, writers, and peacemakers who make silly but thoughtful contributions to the world, or as the Annals of Improbable Research puts it, "first make people laugh, and then make them think." I can vouch for them making us laugh!
Those with 3-years of driving experience and no records of traffic accident crimes, dangerous driving, drugs or drink driving will be allowed to take examinations for online-driving services.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
专注于新兴市场的基金集团经历了难熬的一年，安本(Aberdeen)和安石(Ashmore)的资产管理规模都严重缩水。新兴市场交易所交易基金(ETF)也遭遇大规模赎回，ETF.com数据显示，投资者从贝莱德(BlackRock)旗下基金iShares MSCI Emerging Markets以及先锋(Vanguard)富时新兴市场(FTSE Emerging Markets)撤出95亿美元。
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Will Theresa May remain prime minister in 2018
Gastroenterologists throughout the world will no doubt thank Emmanuel Ben-Soussan and Michel Antonietti for recommending ways that they can minimize patient' gas explosions while the docs perform colonoscopies.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Stripping out price, volumes of Chinese imports in October fell a more modest 2.6 per cent from a year earlier, according to estimates from Oxford Economics.
A robust LinkedIn presence is crucial to any job search. You know that. Your manager knows that. And your manager probably knows that you know that – so she'll be concerned when you go from having a bare-bones profile on Monday to one jacked with additional work history, new connections, status updates and recommendations by Friday. "Don't go from zero to 500 overnight, because that can be quite obvious," Foss cautions。
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The fall in profits in December highlights the challenges facing an industrial sector racked by overcapacity and falling prices, adding to pressure on authorities to loosen monetary policy and boost infrastructure spending to cushion the slowdown.
Lady Gaga ranks fourth with $59 million, followed by Beyoncé at $54.5 million. The former played 66 shows during our scoring period, also cashing in on deals with Versace and MAC, as well as her own Fame fragrance. The latter’s On The Run tour with husband Jay Z grossed over $100 million for 19 North American dates, giving music’s first couple a nightly average comparable to that of the Rolling Stones.
But with a Republican-controlled State Senate, opponents of rent stabilization doubt that 2015 will be a watershed year for the tenants’ movement. Sherwin Belkin, a lawyer who represents landlords, said: “Landlords view this as an opportunity to make some much-needed changes to rent regulation.”
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
China's employment situation is generally stable in the first quarter of 2016, said Li Zhong, Spokesman of the Ministry, adding that the economic downturn and structural reform, however, make employment more difficult.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Major American retailers including Wal-Mart, Target (TGT, Fortune 500), and Kmart all opened their stores on Thanksgiving to get a jump on the holiday gift shopping season. Wal-Mart even went as far as to open its stores two hours earlier this year than it did last. But Costco (COST, Fortune 500) refused to join the trend of "Black Friday creep" and kept its doors shut. Chief executive Craig Jelinek thought giving his workers a day off was more important than increasing his company's bottom line.
Wardrobe malfunctions was another common theme. Some hapless interviewees “showed up in sweatpants,” one “was wearing mismatched shoes,” and another “didn’t realize his zipper was down.”
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Please accept my sincere wishes for the New Year. I hope you will continue to enjoy good health.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Will the Saudi Aramco public offering debut on an international market
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Classic cars:Prices plummet as an enormous supply of post-war classics, hidden away on an off-shore island, becomes available for the first time in 50 years. Collectors are especially eager to find Packards, Studebakers, Hudsons, Nashes, Kaisers, and Henry J’s. More’s the surprise because all of the cars are in running condition and are used as daily drivers.
Anti-HIV drug repurposing against SARS-CoV-2
“The Fed was much more aggressive than expected,” Mr Koepke says. “Taking markets by surprise was clearly not the way to go.” (This was before the Fed began making regular public statements after its monetary policy meetings.)
Despite the overall upward trends in financing, the amount of capital raised by women-owned businesses has historically lagged when compared to men. For example, in the first half of 2013, women made up only 16 percent of businesses seeking funding, with only 24 percent of the women receiving angel funding, Plum Alley, an online e-commerce platform for female entrepreneurs, recently launched a crowdfunding platform specifically focused on helping women innovators get to the next level. And as the first platform of its kind in the exploding crowdfunding space (expected to hit $3.98 billion next year), we can certainly expect Plum Alley to play a big role in the entrepreneurial landscape for women in the year to come.
Length-scale dependence of protein hydration-shell density
Sales & Marketing
Of course, the recovery of the job market has been, and probably will remain, incremental. Job growth needs to be much stronger to actually make a big dent in unemployment, which remains high at 7.9%, though down from 10% three years ago.[qh]
12306.cn, China's official website for purchasing railway tickets, has become the largest of this kind in the world, with combined sales reaching 3.5 billion in 2017.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
10. Drawing Words Helps Your Brain Recall Them
Zhu Yongxin, a member of the CPPCC National Committee, full-time vice-chairman of the Central Committee of the China Association for Promoting Democracy and vice-president of the Chinese Society of Education, talking about an NPC deputy representing 670,000 electorates.
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Even for an industry that generally views history as a grab bag of potential inspiration to be dipped into and mixed and matched at will, this has been extreme.